NextBestNCRM
is the class for next best dose that finds the next dose
with high posterior probability to be in the target toxicity interval.
Arguments
- target
(
numeric
)
see slot definition.- overdose
(
numeric
)
see slot definition.- max_overdose_prob
(
proportion
)
see slot definition.
Details
To avoid numerical problems, the dose selection algorithm has been
implemented as follows: First admissible doses are found, which are those
with probability to fall in overdose
category being below max_overdose_prob
.
Next, within the admissible doses, the maximum probability to fall in the
target
category is calculated. If that is above 5% (i.e. it is not just
numerical error), then the corresponding dose is the next recommended dose.
Otherwise, the highest admissible dose is the next recommended dose.
Slots
target
(
numeric
)
the target toxicity interval (limits included).overdose
(
numeric
)
the overdose toxicity interval (lower limit excluded, upper limit included). It is used to filter probability samples.max_overdose_prob
(
proportion
)
maximum overdose posterior probability that is allowed, except 0 or 1.